41 Years
Physical Sciences
Areas of Expertise
  • Biology
  • Biostatistics
  • Cardiovascular Research
  • Clinical Studies
  • Communications
  • Data Management
  • Drug Development
  • Epidemiology
  • Immunology
  • Journalism
  • Laboratory Animal Science
  • Medicine
  • Metabolic Research
  • Microsurgical Techniques
  • Nursing
  • Oncology
  • Pre-clinical Studies
  • Surgery
  • Toxicology
  • Transplantation
  • Tumor and Immune Biology
  • Veterinary
Bachelor of Arts
· Journalism/Communications, Rider College, 1980

Master of Science
· Laboratory Animal Science, MCP Hahnemann University, 2000

· Continuing Education in Laboratory Animal Science-MNYB-AALAS and NLAEE, 1987
· Intravenous Fluid Therapy & Fluid Volume Replacement in the Small Animal Anesthetic Emergencies and Cardiopulmonary Resuscitation, Delhi State U., 1988
· Large Animal Techniques Surgical Nursing & Anesthesia Techniques for the Laboratory Animal Technician, Delhi State University of New York, 1990
· Laboratory Animal Science and Technology Seminar, Delaware Valley College, 1990
· The CO2 Laser: Basic Concepts, Principles of Laser physics, Clinical Applications, Safety Precautions & Practice Situation; Coherenet Laser Co., 1990
· Endovascular and Laser Surgery Symposium-Harbor UCLA Medical Center, 1990
· Lifesaving, First Aid and CPR, Burlington County College, 1991
· Veterinary Anesthesia Technician Seminar, Cornell University, 1993
· Cardiovascular Tutorial Series, Deborah Research Institute, 1994
· National Animal Welfare Education Workshop: Internal Audits of the Animal Care and Use Program, Medical College of Georgia, 1995
· Introduction to Windows ’95, DH&LC, 1996
· Surgical Research Training Course, Academy of Surgical Research, 1996
· Assertiveness Skills for Managers & Supervisors, 1998
· Catheterization Techniques – Venous and Arterial Porcine Transluminal Coronary Angioplasty, Schering-Plough Research Institute, 1998
· IWCC Scientific Presentations Workshop, Bristol-Myers Squibb, 2000
· Learning to Lead Program, Bristol-Myers Squibb, 2001
· Introduction to Basic Immunology, BMS, 2002
· Certificate in Drug Development and Clinical Research, Mercer County Community College, 2003
· AAI Introductory Course in Immunology Parts I and II, 2005
· AAI Advanced Course in Immunology, Stanford University, 2005
· Certificate in Epidemiology and Biostatistics, Drexel University School of Public Health, 2007
· Introduction to Effective Medical Writing, CfPIE, 2008
· Do’s and Don’ts of Rodent Post-operative Care, Veterinary Bioscience Institute, 2010
· Introduction to Rodent Stereotaxic Surgery, Veterinary Bioscience Institute, 2011
· Essential Skills Certificate Program, American Medical Writers Association, 2016

· Perfusion Assistant, Deborah Heart &Lung Center, 1983-1985
· Experimental Surgery Supervisor/Sr. Lab Animal Technologist, Deborah Research Institute, 1985-1998
· Laboratory Animal Technician, Ethicon, Inc., 1998
· Research Scientist, Bristol-Myers Squibb, 1998-2004
· Senior Research Scientist, Janssen Research and Development, LLC, 2004-Present
· Muralidharan S, Laub G, Gu J, Daloisio C: Tracheal homograft as aortic conduit: Early phase results. Vasc Surg 24:659-665, 1990.

· Gonzalez-Lavin G, Gu J, McGrath LB, Amini S, Cernaianu A, Graf D, Daloisio C: Pulmonary artery balloon counter pulsation for right ventricular failure after right ventriculotomy in the swine. J Thorac Cardiovasc Surg 99:153-160, 1990.

· Laub GW, Muralidharan S, Gu J, Pollock SB, Perritt A, Daloisio C, Adkins M, McGrath LB: A novel system for percutaneous cardiopulmonary bypass. J Investigative Surgery 4:217-230, 1991.

· Muralidharan S, Gu J, Laub GW, Cichon R, Daloisio C, McGrath LB: A new biological membrane for pericardial closure. J Biomed Mater Res 25:1201-1209, 1991.

· Daloisio C, Muralidharan S, Gu J: Sudden death of a young pig during surgery. Lab Animal 21:17-18, 1992.

· Muralidharan S, Gu J, Laub GW, Cichon R, Daloisio C, D’Andrea M, McGrath LB: Results with cryopreserved and glutaraldehyde preserved allograft trachea as an arterial conduit. Vasc Surg 26:24-31, 1992.

· Gu J, Daloisio C, D’Andrea M, Muralidharan S, Cichon R: Physical manipulation of subcutaneously implanted cardiac muscle of rat increased plasma atrial natriuretic peptide concentration. Angiology 43(10): 810-817, October 1992.

· Laub GW, Muralidharan S, Daloisio C, Perritt A, Gu J, Fernandez J, Pollock S, Adkins MS, McGrath LB: Cryopreserved Trachea – A new arterial conduit: Early hemodynamic and radiographic performance. J Vasc Surg 25(8): 642-649, 1991.

· Cichon R, Muralidharan S, Gu J, Fernandez J, Daloisio C, D’Andrea M, Religia Z,
McGrath LB: The cryopreserved stented pulmonary homograft valve in the tricuspid position. J Cardiac Surg Dec; 6(4): 468-75, 1991.

· Gu J, Muralidharan S, D’Andrea M, Daloisio C, Graf D, McGrath LB: Morphologic changes in the transplanted homograft aortic valved conduit: An experimental study. J Thoracic Cardiovasc Surg, June 1991.

· Pacholewicz JK, Daloisio C, Shawarby OA, Muralidharan S, Gu J, McGrath LB: Efficacy of Autologous Peritoneum as a Biological Membrane in Cardiac Surgery. European Journal of Cardiothoracic Surgery 8(10): 563-5, 1994.

· Laub GW, Muralidharan S, Reibman J, FernandezJ, Anderson WA, Gu J, Daloisio C, McGrath LB, Mulligan LJ: Esmolol and percutaneous cardiopulmonary bypass enhance myocardial salvage during ischemia in a dog model. J Thoracic Cardiovascular Surgery 111(5): 1085-1091, May 1996.

· Daloisio C: An Ounce Of Preparation Is Worth A Pound Of Cure. TechTalk, The Newsletter for Laboratory Animal Science Technicians Vol. 7 No.2/2nd Quarter 2002.

· Kliwinski C, Kukral D, Postelnek J, Krishnan B, Killar L, Lewin A, Nadler S, Townsend R: Prophylactic administration of abatacept prevents disease and bone destruction in a rat model of collagen-induced arthritis. J Autoimmunity 25(3):165-171, 2005.

· Kliwinski C, Kukral D, Postelnek J, Krishnan B, Killar L, Nadler S, Townsend R: Prophylactic administration of abatacept (CTLA4Ig; BMS-188667) prevents disease induction and bone destruction in a rat model of collagen-induced arthritis. Arthritis Research & Therapy 01/2005;7.

· Belema M, Bunker A, Nguyen VN, Beaulieu F, Ouellet C, Qui Y, Zhang Y, Martel A, Burke J, McIntyre K, Pattoli M, Daloisio C, Gillooly K, Clarke W, Brassil P, Zusi FC, Vyas D: Synthesis and structure-activity relationship of imidazo(1,2-a)thino(3,2-e)pyrazines as IKK-B inhibitors. Bioorganic & Medicinal Chemistry Letters 17 4284-4289, 2007.

· Scully M, Dryer-Minnerly R, Bendele A, Kliwinski C, Stojanovic-Susulic V, Picha K, Ort T,: Progression of Osteoarthritis in a Mouse Model of Obesity. Osteoarthritis and Cartilage 01/2009;17.

· Moore B, Peffer N, Pirone A, Bassiri A, Saque S, Palmer J, Johnson D, Nesspor T, Kliwinski C, Hornby P: GLP-2 receptor agonism ameliorates inflammation and gastrointestinal stasis in murine post-operative ileus. J of Pharm and Exp Ther DOI:10.1124/jpet.109.161497, February 2010, May 2010, Vol. 333, (2) 574-583.

· Kliwinski C: A treat can be more than just a tasty morsel! Surgical Savvy, Academy of Surgical Research 3-4, July 2010.

· Kliwinski C, Makropoulos D, Kwok D, Volk A, Foster K, Nesspor T, Huang C, Bugelski P: Pharmacokietics and pharmacodynamics of an EPO-mimetic fusion protein in a model of chronic renal insufficiency anemia. The Open Hematology Journal, January 2010,4,17-20.

· Kliwinski C, Cooper P, Perkinson R, Mabus J, Tam S, Wilkinson T, Giles-Komar J, Scallon B, Powers G, Hornby P: The Contribution of FcRn Binding to Intestinal Uptake of IgG in Suckling Rat Pups and Human FcRn-Transgenic Mice. AJP Gastrointestinal and Liver Physiology, February 2013.

· Cooper P, Ciambrone G, Kliwinski C, Maze E, Johnson L, Li Q, Feng Y, Hornby P: Efflux of Monoclonal Antibodies from Rat Brain by Neonatal Fc Receptor, FcRn. Brain Research August 2013.

· Hornby P, Cooper P, Kliwinski C, Ragwan E, Mabus J, Harman B, Thompson S, Kauffman A, Yan Z, Tam S, Dorai H, Powers G, Giles-Komar J: Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis. Pharmaceutical Research, January 2014.

· Cooper P, Kliwinski C, Perkinson R, Ragwan E, Mabus J, Powers G, Dorai H, Giles-Komar J, Hornby P: The contribution of cell surface FcRn in monoclonal antibody serum uptake from the intestine in suckling rat pups. Frontiers in Pharmacology, October 2014.

· Muzammil S, Mabus J, Cooper P, Bement C, Brezski R. Huebert N, Thompson S, Levine D, Kliwinski C, Perkinson R, Bradley D, Hornby P: FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric-coated capsules in cynomolgus macaques. Pharmacology Research & Perspectives, June 2016.

AALAS Workshops
· Swine in the Laboratory, 1986
– Developing Technical Skills in Evaluating Clinical Signs in Lab. Animals Prosector’s Workshop
· Managing the Training Function, 1987
– Good Laboratory Practices in the Animal Research Facility
– Practical Biomedical Photography in Laboratory Animal Science
· Writing Standard Operating Procedures, 1988
– Anesthetic Procedures and Techniques Used in Laboratory Animals
· Rodent and Rabbit Anesthetic Techniques, 1989
– Computerized and Automated Data Collection Systems for Animal Studies
· Getting Results with Work Groups, 1990
· Introduction to Cardiovascular Techniques,1991
· Effective Presentation Techniques, 1992
· Growing from Technical Expert to professional Manager, 2001
– Jugular and Saphenous Blood Collection in the Unanesthetized Mouse
· Implantation Techniques for ALZET Osmotic Pumps, 2003
· American Association for Laboratory Animal Science, Laboratory Animal Technician, 1988
· American Association for Laboratory Animal Science, Registered Laboratory Animal Technologist, 1990
· Academy of Surgical Research, Surgical Research Specialist, 1991
· American Medical Writers Association, Essential Skills Certificate, 2016

· American Medical Writers Association (AMWA)
· Academy of Surgical Research (ASR), Certification committee
· American Association of Laboratory Animal Science (AALAS), Special Projects committee